Chronic Inflammation in Childhood
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Citation: Molecular and Cellular Pediatrics 2024 11:5
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Tipping the balance in autoimmunity: are regulatory t cells the cause, the cure, or both?
Regulatory T cells (Tregs) are a specialized subgroup of T-cell lymphocytes that is crucial for maintaining immune homeostasis and preventing excessive immune responses. Depending on their differentiation rout...
Citation: Molecular and Cellular Pediatrics 2024 11:3 -
The role of regulatory B cells in immune regulation and childhood allergic asthma
As the most common chronic disease in childhood, asthma displays a major public health problem worldwide with the incidence of those affected rising. As there is currently no cure for allergic asthma, it is ma...
Citation: Molecular and Cellular Pediatrics 2024 11:1 -
Phagocytic cell death leads to enhanced release of pro-inflammatory S100A12 in familial Mediterranean fever
Familial Mediterranean fever (FMF) is a prototypical autoinflammatory syndrome associated with phagocytic cell activation. Pyrin mutations are the genetic basis of this disease, and its expression has been sho...
Citation: Molecular and Cellular Pediatrics 2023 10:19 -
Relevance and consequence of chronic inflammation for obesity development
Increasing prevalence of morbid obesity accompanied by comorbidities like type 2 diabetes mellitus (T2DM) led to a demand for improving therapeutic strategies and pharmacological intervention options. Apart fr...
Citation: Molecular and Cellular Pediatrics 2023 10:16 -
A novel serum calprotectin (MRP8/14) particle-enhanced immuno-turbidimetric assay (sCAL turbo) helps to differentiate systemic juvenile idiopathic arthritis from other diseases in routine clinical laboratory settings
Differential diagnosis in children with signs of unprovoked inflammation can be challenging. In particular, differentiating systemic juvenile idiopathic arthritis (SJIA) from other diagnoses is difficult. We h...
Citation: Molecular and Cellular Pediatrics 2023 10:14 -
Autoimmune lymphoproliferative immunodeficiencies (ALPID) in childhood: breakdown of immune homeostasis and immune dysregulation
Many inborn errors of immunity (IEI) manifest with hallmarks of both immunodeficiency and immune dysregulation due to uncontrolled immune responses and impaired immune homeostasis. A subgroup of these disorder...
Citation: Molecular and Cellular Pediatrics 2023 10:11 -
Childhood asthma phenotypes and endotypes: a glance into the mosaic
Asthma is an inflammatory lung disease that constitutes the most common noncommunicable chronic disease in childhood. Childhood asthma shows large heterogeneity regarding onset of disease, symptoms, severity, ...
Citation: Molecular and Cellular Pediatrics 2023 10:9 -
Neuropsychiatric involvement in juvenile-onset systemic lupus erythematosus (jSLE)
Systemic lupus erythematosus (SLE) is a rare autoimmune/inflammatory disease with significant morbidity and mortality. Approximately 15–20% of SLE patients develop the disease during childhood or adolescence (...
Citation: Molecular and Cellular Pediatrics 2023 10:5